The problem (in my case) lays in the wp_cache_add_pages() function (in wp-cache.php):

it calls the add_submenu_page() but not the add_options_page().

Nevertheless, in plugins.php I see a link to

wp-admin/options-general.php?page=wpsupercache

that gaves this error 500…

wp-admin/ms-admin.php?page=wpsupercache

works though…

Any thoughts?