I’ve got most of the best anti-spam tricks in place. Including the old standby Spam Karma 2. One thing that always got me though.
With SK2, even if the karma was like -50, it still was kept on the site waiting for me to manually purge it.
Finally wrote my own SK2 plugin that lets you block spammy comments. Not just quarantine.
http://pirate-king.com/episode/2441
Since then, I am no longer greeted with “You have 87 spam comments in your queue” which makes me very happy.