Thoughts on a Sharpening Workflow – if you don’t know about sharpening, have a read of this lengthy article.
The author makes the case for 3 sharpening stages in a successfull workflow.
Be aware however if you excessively sharpen an image you’ll lose detail and introduce halos around contrasting elements of the image.
I generally leave sharpening to the end, and apply an unsharp mask just before saving.